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Our new Distinct+ tissue clearing approach is the one technique that delipidates samples without having alter in morphology and with negligible effect on structural integrity.

Megatome can be a vibrating microtome meant to part a broad selection of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With large blade vibrating frequency and minimized blade deflection, Megatome allows substantial-throughput tissue sectioning with uniform floor profile, together with negligible tissue injury and information reduction.

Antibodies could get weeks to diffuse by way of just a few millimeters of tissue, using a steep labeling gradient from surface area to core.

Megatome is suitable for accuracy: the blade vibrates at a higher frequency and larger amplitude variety than other microtomes, and contains a exceptional deflection Regulate mechanism.

SE employs a rotational electrical area to disperse hugely electromobile molecules (such as antibodies or surfactant micelles) during a porous sample without having damaging electrically charged structures within the tissue. This enables 2-four working day clearing of intact organs,

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Megatome is usually a novel microtome which allows for prime-precision sectioning of a wide range of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with small tissue hurt and information decline.

eFLASH is really a immediate tissue labeling strategy that allows for uniform total-organ staining in 20 rounds of labeling.

The SmartSPIM light sheet microscope delivers unparalleled resolution and acquisition speed in the course of intact tissue volumes, although its modular design helps you to update and customise personal factors.

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Either obtain a release or produce a distribution zip as outlined higher than. Unzip the archive to a wanted site.

Leverage the Apparent+ tissue clearing technique, in addition to eFLASH and patented stochastic electrotransport systems, to fast clear and label entire organs. Crucial highlights and capabilities involve:

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